Minoxidil Research Guide
Minoxidil is a potassium channel opener and one of the most widely studied reference compounds in vascular and follicle biology. This guide covers its background, mechanism and handling.
At a glance
- CAS number: 38304-91-5
- Molecular formula: C9H15N5O
- Class: piperidinopyrimidine derivative; ATP-sensitive potassium (KATP) channel opener
Origin
Minoxidil was developed by Upjohn in the 1960s and 1970s and first studied as an oral vasodilator for blood pressure research.
Mechanism
Minoxidil is a prodrug. The enzyme sulfotransferase converts it to minoxidil sulfate, the active form, which opens ATP-sensitive potassium channels in cell membranes. In vascular smooth muscle this causes relaxation and vasodilation. Because sulfotransferase activity varies between tissues and individuals, it is an important variable in study design.
Research use
Minoxidil is commonly used as a reference or comparator compound in studies of potassium channel activity, vascular tone and follicle biology, including alongside androgen receptor antagonists such as RU58841.
Storage and handling
- Store below 25°C, away from direct light.
- Keep the cap tightly closed; solutions may contain flammable solvents.
- Wear gloves and eye protection, and work in a well-ventilated area.
- Keep out of reach of children.
Research use only
Mane Regain supplies minoxidil solution strictly for laboratory research. It is not intended for human or veterinary use, consumption or application.